Fig. 1 | Modern Pathology

Fig. 1

From: miRNA profiling of small intestinal neuroendocrine tumors defines novel molecular subtypes and identifies miR-375 as a biomarker of patient survival

Fig. 1

Clustering analysis of small intestinal neuroendocrine tumors from 37 patients. Unsupervised hierarchical clustering analysis was performed on miRNA profiles from tumors and normal small intestinal mucosa. Tumors were separated into 3 distinct groups, denoted cluster P, cluster M1, and cluster M2. The majority of the primary tumors clustered together in cluster P, whereas metastases were separated in 2 different clusters, a smaller cluster M1 and a larger cluster M2. Types of tissue analyzed are indicated: M, metastasis; N, normal small intestinal mucosa; P, primary tumor. Paired tumor samples (primary and metastases) were available from 5 patients, indicated by a, b, c, d, and e (for details, see Table 1)

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