Table 1 Clinicopathological characteristics of patients with small intestinal neuroendocrine tumors subjected to miRNA profiling

Case number	Age at diagnosis	Gender	Grade (WHO 2010)^f	Mitotic count (per 10 HPF)	Ki67, %	Stage (TNM 7th edn)^g	Follow-up, months	Current status	Primary surgery	Tumor site for miRNA profiling
1	64	F	G1	0.4	0.5	IV	40	DWD	Yes	P
2	68	M	G2	0.2	5.3	IV	16	DWD	Yes	P
3	59	M	G1	1.4	2	IIIB	110	NED	Yes	P
4	58	F	G1	0.2	0.7	IV	168	AWD	Yes	P
5	74	F	G1	< 0.2	0.5	IV	78	DWD	Yes	P
6	68	M	G1	< 0.2	0.4	IV	18	DWD	Yes	P
7^a	53	M	G1	< 0.2	0.5	IV	61	DWD	Yes	P
			G1	0.4	1				Yes	L
8^b	80	F	G1	< 0.2	0.5	IV	142	DWD	Yes	P
			G1	0.4	1.1				Yes	L
9	81	F	G1	0.2	2	IV	35	DWD	Yes	P
10	42	F	G1	0.6	1.9	IV	201	AWD	Yes	P
11	79	M	G1	0.2	0.7	IV	29	DWD	Yes	P
12	49	M	G2	1.4	6	IV	5	DWD	Yes	P
13^c	71	F	G1	< 0.2	1.5	IV	60	DWD	Yes	P
			G2	3.8	5.2					L
14^d	56	F	G1	< 0.2	0.4	IV	12	DWD	Yes	P
			G3	8.4	30.4				Yes	L
15^e	73	M	G2	1	3.4	IV	6	DWD	Yes	P
			G2	5.5	8.6				Yes	L
16	60	M	G1	1	1	IV	35	DWD	Yes	L
17	75	F	G2	0.6	9.9	IV	32	DWD	Yes	L
18	53	M	G1	0.4	2.6	IIIB	142	AWD	Yes	L
19	47	F	G2	0.6	5.5	IIIB	94	AWD	Yes	L
20	74	M	G2	2.2	4.7	IV	11	DWD	Yes	L
21	61	F	G2	4.4	16.7	IV	4	DWD	Yes	L
22	70	F	G2	7	11.7	IV	13	DWD	Yes	L
23	73	F	G2	4.6	11.2	IV	19	DWD	Yes	L
24	63	M	G1	< 0.2	0.6	IV	163	AWD	Yes	P
25	53	F	G1	< 0.2	0.4	IV	155	AWD	Yes	LN
26	64	M	G1	0.6	0.2	IV	94	DWD	Yes	L
27	64	F	G1	0.4	0.7	IV	116	NED	Yes	L
28	71	M	G1	< 0.2	2.1	IV	82	DWD	Yes	L
29	61	F	G1	< 0.2	0.7	IV	98	AWD	Yes	L
30	51	M	G1	< 0.2	0.9	IV	105	AWD	Yes	L
31	71	M	G2	2.2	1.6	IV	124	DWD	Yes	L
32	56	F	G1	0.2	1.3	IV	42	DWD	Yes	L
33	74	M	G1	0.2	0.3	IV	34	DWD	Yes	L
34	70	M	G1	< 0.2	0.6	IV	91	AWD	Yes	L
35	75	F	G1	0.4	2.4	IV	40	DWD	Yes	L
36	59	M	G1	0.2	0.6	IV	71	DWD	Yes	LN
37	72	M	G1	< 0.2	0.8	IV	130	AWD	Yes	L

Abbreviations: AWD, alive with disease; DWD, dead with disease; F, female; HPF, high power fields; L, liver metastases; LN, lymph node metastases; M, male; NED, no evidence of disease; P, primary tumor. ^a, ^b, ^c, ^d, and ^e; cases with paired tumor samples (primary and liver metastases), ^f WHO 2010 (see ref. [19]), ^gTNM 7th edn (see ref. [20])

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