Table 1 Clinicopathological features of our 188 patients with advanced urothelial bladder cancer treated with adjuvant chemotherapy

From: Reappraisal of HER2 status in the spectrum of advanced urothelial carcinoma: a need of guidelines for treatment eligibility

Variable

N (%) or variable unit

Median age (years) at cystectomy (range)

62 (35–79)

Gender

  Female

31 (17)

  Male

157 (83)

pT stage, N (%)

 T0

7 (4)

 Tis

1 (1)

 Ta

1 (1)

 T1

4 (2)

 T2

25 (13)

 T3

94 (50)

 T4

56 (29)

pN stage, N (%)

 Nx

18 (9)

 N0

28 (15)

 N1

45 (24)

 N2

96 (51)

 N3

1 (1)

Treatment

Adjuvant chemotherapy regimen

 G

1 (1)

 GC

131 (69)

 GCb

45 (24)

 MVAC

9 (5)

Other

2 (1)

Histological variant of primary tumors (N = 178)*

Pure conventional urothelial carcinoma

68 (38)

Urothelial carcinoma with divergent differentiation

  Squamous differentiation

44 (25)

  Glandular differentiation

4 (2)

Micropapillary carcinoma

50 (28)

  Pure micropapillary carcinoma

20

  Mixte micropapillary carcinoma

30

Plasmacytoid/single-cell carcinoma

13 (7)

Sarcomatoid carcinoma

23 (13)

Giant cell

1 (1)

Microcystic

1 (1)

  1. A doxorubicin, G gemcitabine, C cisplatin, Cb carboplatin, M methotrexate, V vinblastine
  2. *Sum of percentages above 100% due to tumor heterogeneity