Table 4 Characteristics of primary tumors and matched lymph node metastases with HER2 heterogeneous expression
Case | Histological variant | Homogeneity for HER2 IHC score | HER2 membrane staining intensity | FISH | |
|---|---|---|---|---|---|
#1 | T | Squamous differentiation | Heterogeneous | Absent | Negative |
T | Micropapillary | Moderate | Positive | ||
LN | Conventional | Heterogeneous | Weak | Equivocal | |
LN | Micropapillary | Moderate | Positive | ||
#2 | T | Conventional | Heterogeneous | Weak | Negative |
T | Glandular differentiation | Moderate | Positive | ||
LN | Conventional | Homogeneous | Moderate | Equivocal | |
LN | Micropapillary | Moderate | Equivocal | ||
#3 | T | Conventional | Homogeneous | Moderate | Negative |
T | Micropapillary | Moderate | Negative | ||
LN | Conventional | Heterogeneous | Weak | Negative | |
LN | Micropapillary | Moderate | Equivocal | ||
#4 | T | Conventional | Heterogeneous | Weak | Negative |
T | Conventional | Moderate | Equivocal | ||
LN | Squamous differentiation | Heterogeneous | Weak | NC | |
LN | Squamous differentiation | Moderate | NC | ||
#5 | T | Conventional | Heterogeneous | Weak | Negative |
T | Micropapillary | Moderate | Negative | ||
LN | Conventional | Homogeneous | Moderate | Negative | |
LN | Micropapillary | Moderate | Negative | ||
#6 | T | Conventional | Homogeneous | Weak | NC |
T | Micropapillary | Weak | NC | ||
LN | Conventional | Heterogeneous | Weak | Negative | |
LN | Micropapillary | Moderate | Positive | ||
#7 | T | Squamous differentiation | Heterogeneous | Weak | Negative |
T | Micropapillary | Strong | Positive | ||
#8 | T | Conventional | Heterogeneous | Weak | Negative |
T | Micropapillary | Strong | Equivocal | ||
LN | Micropapillary | Homogeneous | Moderate | NC | |
#9 | T | Conventional | Heterogeneous | Weak | Negative |
T | Micropapillary | Moderate | Negative | ||
#10 | T | Conventional | Heterogeneous | Absent | Negative |
T | Conventional | Moderate | Negative | ||
#11 | T | Conventional | Heterogeneous | Absent | Negative |
T | Plasmacytoid | Moderate | Equivocal | ||
LN | Conventional | Homogeneous | Moderate | NC | |
#12 | T | Sarcomatoid | Heterogeneous | Absent | Negative |
T | Squamous differentiation | Moderate | Positive | ||
LN | Sarcomatoid | Homogeneous | Moderate | Negative | |
LN | Squamous differentiation | Moderate | Negative | ||
#13 | T | Conventional | Homogeneous | Moderate | Equivocal* |
LN | Conventional with extra capsular extension | Heterogeneous | Weak | Equivocal** | |
LN | Conventional carcinoma within sinuses | Moderate | Equivocal*** |
