Fig. 4

Comparison of the genetic susceptibility for recurrent hydatidiform moles between patients with and without recessive mutations in NLRP7 or KHDC3L. a A significantly lower number of familial cases was found in patients without NLRP7 or KHDC3L mutations (p = 0.00029). b A history of <3 pregnancy losses was more frequent in patients without mutations in either gene while a history of 4–6 pregnancy losses or at least 7 pregnancy losses was more frequent in patients with NLRP7 or KHDC3L mutations. c Patients without mutations in either gene had a significantly higher number of live births than patients with mutations (p = 0).