Table 2 Frequency of TILs density in different topographic areas and their association with outcome in terms of recurrence-free interval in the training set
From: Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast
Parameter | TILs density (mean number of TILs/DCIS duct as cutoff) | Number of cases (%) | Recurrence (%) | p-value (log-rank test) |
|---|---|---|---|---|
Touching TILs (two-tier system) | Sparse (≤20) | 70 (47) | 6 (15) | 4.7 × 10−6 |
Dense (>20) | 80 (53) | 35 (85) | ||
Touching TILs (three-tier system) | Absent/very scanty (≤5) | 7 (5) | 0 (0) | 2.0 × 10−5 |
Sparse (6–20) | 63 (42) | 6 (15) | ||
Dense (>20) | 80 (53) | 35 (85) | ||
TILs at 0.2 mm distance | Sparse (≤60) | 64 (43) | 8 (20) | 0.001 |
Dense (>60) | 86 (57) | 33 (80) | ||
TILs at 0.5 mm distance | Sparse (≤100) | 61 (41) | 8 (20) | 0.002 |
Dense (>100) | 89 (59) | 33 (80) | ||
TILs at 1.0 mm distance | Sparse (≤120) | 53 (35) | 6 (15) | 0.001 |
Dense (>120) | 97 (65) | 35 (85) | ||
Hotspot | Sparse (≤1200) | 103 (69) | 33 (80) | 0.089 |
Dense (>1200) | 47 (31) | 8 (20) | ||
Lymphoid follicles | No | 119 (79) | 36 (88) | 0.150 |
Yes | 31 (21) | 5 (12) | ||
Percentage of stromal TILs | Sparse (≤5%) | 77 (51) | 15 (37) | 0.020 |
Dense (>5%) | 73 (49) | 26 (63) |
