Table 3 Correlation between TILs density (based on mean number of touching TILs with cutoff 20 cells/DCIS duct) and clinicopathological parameters in the validation set
From: Prognostic significance of tumor-infiltrating lymphocytes in ductal carcinoma in situ of the breast
Parameter | TILs density | Chi square (χ2) | p-value | ||
|---|---|---|---|---|---|
Dense N (%) | Sparse N (%) | ||||
Patient age | |||||
≤50 years | 71 (52) | 65 (48) | 4.09 | 0.043 | |
>50 years | 168 (42) | 230 (58) | |||
Presentation | |||||
Screening | 114 (41) | 166 (59) | 3.89 | 0.049 | |
Symptomatic | 125 (49) | 129 (51) | |||
DCIS Size | |||||
≤20 mm | 85 (37) | 147 (63) | 10.66 | 0.001 | |
>20 mm | 152 (51) | 147 (49) | |||
DCIS Grade | |||||
Low | 8 (14) | 49 (86) | 41.18 | 1.1 × 10−9 | |
Moderate | 44 (33) | 88 (67) | |||
High | 187 (54) | 158 (46) | |||
Comedo type necrosis | |||||
Yes | 185 (50) | 182 (50) | 15.16 | 0.00009 | |
NO | 54 (32) | 113 (68) | |||
Associated Paget’s disease | |||||
Yes | 18 (69) | 8 (31) | 5.03 | 0.025 | |
No | 156 (46) | 180 (54) | |||
Estrogen receptor status | |||||
Negative | 83 (72) | 33 (28) | 41.73 | 1.04 × 10−10 | |
Positive | 114 (36) | 198 (64) | |||
Type of DCIS | |||||
Mixed with invasion | 105 (80) | 27 (20) | 51.29 | 8.96 × 10−13 | |
Pure DCIS | 239 (45) | 295 (55) | |||
