Fig. 5

Kaplan–Meier survival curves of disease-free survival (DFS). Patients segregated according to adrenocortical carcinoma variants (p = 0.01), Weiss score (p = 0.01), mitotic index (p = 0.004), Ki-67 index (p = 0.0004), Helsinki score (p = 0.002), and to the median number of somatic alterations in β-catenin (p = 0.04), p53/Rb (p = 0.02) and chromatin-remodeling (p = 0.03) pathways. MB mutational burden, Chr Rem chromatin remodeling, Rb retinoblastome