Fig. 6

Overview of somatic alterations identified for matched primary and recurrent/metastatic tissues in 10 adrenocortical carcinoma samples. Distribution of tumor-specific somatic variants and copy number changes are illustrated in the heatmap showing for each sample the corresponding recurrence/metastasis. Left: genes are clustered according to specific signaling pathways; right: histograms of timeframe alterations among genes. Main clinical and pathological features are detailed above