Fig. 2

Progression of chronic hepatitis liver disease. a Schematic of normal hepatic parenchyma. b Early parenchymal extention (*; red-brown) forms when there are vascular thrombosis to two vessels of hepatic parenchymal blood supply (portal veins and central vein here; black indicating occlusion). Early parenchymal extinction is marked by inflammation, macrophages, activation of hepatic stellate cells, minimal collagen deposition. c Progressing parenchymal extinction (*; dark brown) has increasing deposition of collagen with broad fibrous septa. These are variably inflamed. Hepatic stellate cells remain prominent. Ductular reactions may be present. d With quiescent disease, fibrotic septa are dense and well formed. Inflammation is less. Stellate cells may still be active, though often less prominently. e Regressing septa are densely compacted, acellular. There may be fragmentation. Vascular thrombosis may be demonstrably recanalized. Elastin fibers are prominent with special stains. F. Regression may be complete in some cases, though distortion of parenchymal anatomy may be recognizable, central veins and portal tracts in abnormal proximity