Table 1 Clinicopathologic correlation of PD-L1 expression by 22C3 PharmDx in non-small cell lung cancer and adenocarcinoma
PD-L1 Expression in non-small-cell lung cancer | PD-L1 expression in adenocarcinoma | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
≥50% | ≥1% | ≥50% | ≥1% | ||||||||
n = 713 | 149 (21%) | P-value | 396 (56%) | P-value | n = 399 | 46 (12%) | P-value | 187 (46%) | P-value | ||
Age | <60 | 240 | 48 (20%) | 126 (53%) | 145 | 14 (10%) | 60 (41%) | ||||
≥60 | 473 | 101 (21%) | 0.675 | 270 (57%) | 0.245 | 254 | 32 (13%) | 0.376 | 123 (48%) | 0.174 | |
Gender | Female | 226 | 30 (13%) | 112 (50%) | 173 | 11 (6%) | 74 (43%) | ||||
Male | 487 | 119 (24%) | 0.001 | 284 (58%) | 0.029 | 226 | 35 (16%) | 0.005 | 109 (48%) | 0.278 | |
Smoking | Never smoker | 231 | 29 (13%) | 105 (46%) | 183 | 11 (6%) | 71 (39%) | ||||
Ever smoker | 409 | 102 (25%) | <0.001 | 249 (61%) | <0.001 | 172 | 28 (16%) | 0.002 | 91 (53%) | 0.008 | |
Stage | I-IIIA | 597 | 128 (21%) | 336 (56%) | 322 | 40 (12%) | 149 (46%) | ||||
IIIB-IV | 104 | 16 (15%) | 0.158 | 54 (52%) | 0.409 | 72 | 4 (6%) | 0.094 | 31 (43%) | 0.620 | |
N status | Negative | 406 | 77 (19%) | 218 (54%) | 227 | 23 (10%) | 98 (43%) | ||||
Positive | 276 | 64 (23%) | 0.181 | 161 (58%) | 0.231 | 158 | 22 (14%) | 0.255 | 81 (51%) | 0.117 | |
Histology | Adenocarcinoma | 399 | 46 (12%) | <0.001 | 183 (46%) | <0.001 | — | — | — | — | — |
Squamous cell carcinoma | 189 | 55 (29%) | 0.001 | 116 (61%) | 0.060 | — | — | — | — | — | |
Large cell carcinoma | 50 | 21 (42%) | <0.001 | 39 (78%) | 0.001 | — | — | — | — | — | |
Adenosquamous carcinoma | 25 | 4 (16%) | 0.540 | 15 (60%) | 0.648 | — | — | — | — | — | |
Lymphoepithelioma-like carcinoma | 29 | 12 (41%) | 0.006 | 27 (93%) | <0.001 | — | — | — | — | — | |
Sarcomatoid carcinoma | 21 | 11 (52%) | <0.001 | 16 (76%) | 0.053 | — | — | — | — | — | |
EGFR | Wild type | — | — | — | — | — | 223 | 35 (16%) | 112 (50%) | ||
Mutant | — | — | — | — | — | 176 | 11 (6%) | 0.003 | 71 (40%) | 0.049 | |
KRAS | Wild type | — | — | — | — | — | 352 | 35 (10%) | 154 (44%) | ||
Mutant | — | — | — | — | — | 46 | 11 (24%) | 0.005 | 29 (63%) | 0.014 | |
ALK | Wild type | — | — | — | — | — | 381 | 44 (12%) | 175 (46%) | ||
Mutant | — | — | — | — | — | 18 | 2 (12%) | 0.955 | 8 (44%) | 0.902 | |
ROS1 | Wild type | — | — | — | — | — | 378 | 44 (12%) | 174 (46%) | ||
Mutant | — | — | — | — | — | 9 | 2 (22%) | 0.332 | 5 (56%) | 0.571 | |
MET | Wild type | — | — | — | — | — | 333 | 40 (12%) | 149 (45%) | ||
Mutant | — | — | — | — | — | 14 | 3 (21%) | 0.295 | 7 (50%) | 0.699 | |
