Fig. 5

Refined classification of high-risk endometrial cancer based on DNA damage response biomarkers with specific therapeutic strategies associated. High-risk endometrial cancer molecular subgroups characteristics (a) and algorithm (b) using DNA damage response biomarkers. “No specific molecular profile” and “TP53 mutated” molecular subgroups were refined according to their DNA damage response positivity/negativity using respectively “DNA damage” and “error prone Non Homologous End-Joining” biomarkers: (1) POLE mutated (POLE)/microsatellite instable (MSI), (2) no specific molecular profile/δ-H2AX negative (NSMP δ-H2AX-), (3) TP53 mutated/Non Homologous End-Joining negative (P53 NHEJ−), (4) no specific molecular profile/δ-H2AX positive (NSMP δ-H2AX+), and (5) TP53 mutated/Non Homologous End-Joining positive (P53 NHEJ+). «Error-prone Non Homologous End-Joining» positive defined as “DNA-pk+/FANCD2−»; «DNA damaged» defined as δ-H2AX positive