Table 1 Dynamic change in histological features between the four group
All n = 117 | Fast reverse (9%) | Reverse (63%) | Stable (15%) | Progress (13%) | P value | |
|---|---|---|---|---|---|---|
Baseline | ||||||
HAI score, n (%) | 0.107 | |||||
0–3 | 7 (6.0) | 0 (0.0) | 4 (5.4) | 1 (5.9) | 2 (13.3) | |
4–6 | 44 (37.6) | 3 (27.3) | 25 (33.8) | 8 (47.1) | 8 (53.3) | |
7–9 | 41 (35.0) | 6 (54.5) | 24 (32.4) | 8 (47.1) | 3 (20.0) | |
≥10 | 25 (21.4) | 2 (18.2) | 21 (28.4) | 0 (0.0) | 2 (13.3) | |
Ishak stage, n (%) | 0.002** | |||||
2 | 2 (1.7) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (13.3) | |
3 | 48 (41.0) | 3 (27.3) | 25 (33.8) | 13 (76.5) | 7 (46.7) | |
4 | 44 (37.6) | 4 (36.4) | 32 (43.2) | 3 (17.6) | 5 (33.3) | |
5 | 19 (16.2) | 2 (18.2) | 16 (21.6) | 0 (0.0) | 1 (6.7) | |
6 | 4 (3.4) | 2 (18.2) | 1 (1.4) | 1 (5.9) | 0 (0.0) | |
qFibrosis | 3.6 (2.8, 4.5) | 4.4 (2.8, 5.5) | 3.7 (2.9, 4.7) | 3.2 (2.5, 3.6) | 2.3 (1.9, 3.8) | 0.001*** |
Week 78 | ||||||
HAI score, n (%) | 0.654 | |||||
0–3 | 44 (37.6) | 5 (45.5) | 29 (39.2) | 7 (41.2) | 3 (20.0) | |
4–6 | 70 (59.8) | 6 (54.5) | 43 (58.1) | 10 (58.8) | 11 (73.3) | |
7–9 | 3 (2.6) | 0 (0.0) | 2 (2.7) | 0 (0.0) | 1 (6.7) | |
≥10 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
Ishak stage, n (%) | <0.001*** | |||||
1 | 3 (2.6) | 3 (27.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
2 | 19 (16.2) | 4 (36.4) | 15 (20.3) | 0 (0.0) | 0 (0.0) | |
3 | 55 (47.0) | 3 (27.3) | 32 (43.2) | 13 (76.5) | 7 (46.7) | |
4 | 22 (18.8) | 1 (9.1) | 14 (18.9) | 3 (17.6) | 4 (26.7) | |
5 | 17 (14.5) | 0 (0.0) | 13 (17.6) | 0 (0.0) | 4 (26.7) | |
6 | 1 (0.9) | 0 (0.0) | 0 (0.0) | 1 (5.9) | 0 (0.0) | |
qFibrosis | 2.7 (2.1, 3.5) | 2.5 (1.8, 3.2) | 2.4 (2.0, 3.2) | 3.1 (2.4, 3.8) | 3.3 (2.6, 4.5) | 0.012* |
Change | ||||||
ΔHAI | −3.0 (−5.0, −1.0) | −3.0 (−5.0, −2.0) | −3.0 (−6.0, −1.8) | −2.0 (−3.0, −1.0) | −1.0 (−3.0, 0.0) | 0.001** |
ΔIshak | 0.0 (−1.0, 0.0) | −2.0 (−2.0, −2.0) | −1.0 (−1.0, −1.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 1.0) | <0.001*** |
ΔqFibrosis | −0.8 (−1.6, 0.0) | −1.9 (−2.8, −0.8) | −1.2 (−1.6, −0.7) | 0.0 (−0.2, 0.3) | +0.7 (0.3, 1.1) | <0.001*** |
