Table 1 Risk factors of lymph node metastasis in early (pT1) gastric cardiac carcinoma

From: Low risk of lymph node metastasis in 495 early gastric cardiac carcinomas: a multicenter clinicopathologic study of 2101 radical gastrectomies for early gastric carcinoma

Clinicopathologic factor

Lymph node metastasis (%)

p value

Total number

Present

Absent

Number

 

495

33 (6.7)

462 (93.3)

 

Gender

Male

374 (75.6)

24 (72.7)

350 (75.8)

NS

 

Female

121 (24.4)

9 (27.3)

112 (24.2)

 
 

M/F ratio

3.1

2.7

3.1

NS

Age (Year)

Average (SD)

65.4 (8)

64.5 (9.5)

65.4 (7.9)

NS

 ≤ 49

17 (3.4)

1 (3)

16 (3.5)

NS

50–59

88 (17.8)

9 (27.3)

79 (17.1)

NS

60–69

231 (46.7)

13 (39.4)

218 (47.2)

NS

 ≥ 70

159 (32.1)

10 (30.3)

149 (32.3)

NS

 < 60

105 (21.2)

10 (30.3)

95 (20.6)

NS

 ≥ 60

390 (78.8)

23 (69.7)

367 (79.4)

Macroscopic feature

0–I

45 (9.1)

2 (6.1)

43 (9.3)

NS

0–IIa

95 (19.2)

8 (24.2)

87 (18.8)

NS

0–IIb

136 (27.5)

8 (24.2)

128 (27.7)

NS

0–IIc

138 (27.9)

10 (30.3)

128 (27.7)

NS

0–III

81 (16.4)

5 (15.2)

76 (16.5)

NS

0–I to 0–IIa

140 (28.3)

10 (30.3)

130 (28.1)

NS

0–IIb

136 (27.5)

8 (24.2)

128 (27.7)

NS

0–IIc + 0–III

219 (44.2)

15 (45.5)

204 (44.2)

NS

Size (cm)

 ≤ 0.9

76 (15.4)

1 (3)

75 (16.2)

 < 0.05

1.0–1.9

159 (32.1)

7 (21.2)

152 (32.9)

NS

2.0–2.9

159 (32.1)

9 (27.3)

150 (32.5)

NS

 > 3.0

101 (20.4)

16 (48.5)

85 (18.4)

 < 0.0001

Invasion depth

M2

63 (12.7)

0

63 (13.6)

 < 0.05

M3

130 (26.3)

0

130 (28.1)

 < 0.0001

SM1

115 (23.2)

10 (30.3)

105 (22.7)

NS

SM2

187 (37.8)

23 (69.7)

164 (35.5)

 < 0.0001

Histology type

Tubular adenocarcinoma

326 (65.9)

18 (54.5)

308 (66.7)

NS

Papillary adenocarcinoma

106 (21.4)

8 (24.2)

98 (21.2)

NS

Poorly cohesive carcinoma

11 (2.2)

2 (6.1)

9 (1.9)

NS

Mucinous carcinoma

7 (1.4)

1 (3)

6 (1.3)

NS

Micropapillary adenocarcinomaa

11 (2.2)

1 (3)

10 (2.2)

NS

Mixed PCC and tubular/papillary adenocarcinoma

21 (4.2)

4 (12.1)

17 (3.7)

 < 0.05

Mixed mucinous and tubular/papillary adenocarcinoma

14 (2.8)

0

14 (3)

NS

Neuroendocrine (N = 4) medullary (N = 4), adenosquamous (N = 2) carcinoma

10 (2)

0

10 (2.2)

NS

Differentiation

Well

158 (31.9)

2 (6.1)

156 (33.8)

 < 0.0001

Moderate

226 (45.7)

15 (45.5)

211 (45.7)

NS

Poorly

111 (24.4)

16 (48.5)

95 (20.6)

 < 0.0001

Lymphovascular invasion

Absence

440 (88.9)

17 (51.5)

423 (91.6)

 < 0.00001

Presence

55 (11.1)

16 (48.5)

39 (8.4)

Perineural invasion

Absence

483 (97.6)

31 (93.9)

452 (97.8)

NS

Presence

12 (2.4)

2 (6.1)

10 (2.2)

  1. a Micropapillary adenocarcinoma was present as a minor component and excluded from the frequency (%) calculation as a major subtype of carcinoma in the cohort
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