Table 2 Clinical and anatomopathological characteristics of oncocytic adrenocortical tumors, good vs. poor outcomes
Characteristicsa | Good outcome | Poor outcome |
|---|---|---|
Sex (female) | 23 (57.5%) | 2 F/1M |
Age (years) | 47.5 (38.0–55.8) | 46, 50, 59 |
Tumor size (cm) | 6.8 (4.5–9.9) | 8.5, 10, 21 |
Tumor weight (g) | 161 (59–392) | 80, 176, 2940 |
Hormonal production | 20 (54%) | 2/3 (1 cortisol, 1 cortisol and androgen) |
Pure oncocytic tumors | 26 (65%) | 2/3 |
Dominant diffuse architecture | 35 (88%) | 2/3 |
Mitotic index > 5/50 HPF | 20 (50%) | 3/3 |
Atypical mitosis | 21 (53%) | 3/3 |
Capsular invasion | 9 (23%) | 2/3 |
Venous invasion | 7 (18%) | 2/3 |
Sinusoidal invasion | 0 (0%) | 1/3 |
Necrosis | 13 (33%) | 3/3 |
Reticulin stain: disrupted | 32 (91%) | 3/3 |
Ki-67 PI (%) | 3 (1–3.5) | 7, 14, 15 |
ENS@T (III or IV) | 3 (8%) (only stage III) | 3/3 III, III and IV |
Different approaches by scores | ||
Weiss score | 5 (3–6) | 7, 7, 8 |
Lin–Weiss–Bisceglia score (borderline, malignant) | 6 Borderline (15%), 25 Malignant (63%) | 3 Malignant |
Reticulin algorithm (malignant) | 20 (56%) | 3 |
Helsinki score | 6 (3–9.5) | 15, 22, 23 |
