Fig. 4

Transcriptomic classification of dermatofibrosarcoma protuberans. Unsupervised hierarchical clustering, using the top 10% most variant genes based on interquantile range, comparing PDGFB-rearranged dermatofibrosarcoma protuberans (n = 8, including 3 “conventional” dermatofibrosarcomas protuberans positive for PDGFB rearrangement using FISH analysis), PDGFD-rearranged dermatofibrosarcoma protuberans (n = 9), infantile fibrosarcomas (n = 7), clear cell sarcomas of soft tissue (superficially seated) (n = 2), ALK-rearranged Spitzoid neoplasms (n = 5), and NTRK1/3-rearranged Spitzoid neoplasms (n = 7). Branches depicted with colors within the dendrogram were found significant (p value < 10e-5) by SigClust clustering significance assessment. Samples are listed in Table 1 and Supplementary Table 4. Infantile fibrosarcomas are highlighted in purple, low grade fibromyxoid sarcomas in orange, spitzoid neoplasms in yellow, clear cell sarcomas in light red, and dermatofibrosarcoma protuberans in red