Table 2 Bone marrow histologic findings in 23 patients with hairy cell leukemia-variant

Case #	BM cellularity, %	BM leukemic involvement, %	Primary pattern	Secondary pattern	Cell size	Projections	Nucloli	Amount of cytoplasm	Dysplasia
1	60	34	Interstitial		Intermediate	Yes	Inconspicuous	Moderate	No
2	70	17	Interstitial	Sinusoidal	Intermediate	Yes	Inconspicuous	Moderate	Yes
3	40	80	Interstitial		Large	Yes	Prominent	Moderate	No
4	70	80	Interstitial		Large	Yes	Prominent	Abundant	No
5	50	28	Interstitial	Sinusoidal	Large	Yes	Prominent	Abundant	No
6	80	73	Interstitial	Sinusoidal	Intermediate	Yes	Prominent	Moderate	No
7	40	50	Interstitial	Sinusoidal	Intermediate	Yes	Prominent	Abundant	No
8	50	20	Interstitial		Intermediate	Yes	Prominent	Moderate	No
9	30	15	Sinusoidal	Interstitial	Intermediate	Rare	No	Abundant	No
10	30	20	Sinusoidal	Interstitial	Small	Yes	Rare	Abundant	No
11	40	50	Interstitial	Sinusoidal	Intermediate^a	Yes	Rare	Abundant	No
12	90	80	Interstitial	Sinusoidal	Intermediate	Yes	Rare	Abundant	No
13	80	80	Interstitial		Intermediate	Rare	No	Abundant	Mild
14	60	40	Interstitial	Sinusoidal	Intermediate	Yes	Rare	Moderate	No
15	95	84	Diffuse	Interstitial	Large	Yes	Prominent	Abundant	No
16	30	40	Interstitial	Nodular	Intermediate	Rare	Prominent	Moderate	No
17	95	50	Interstitial		Intermediate	Yes	No	Moderate	No
18	85	70	Diffuse	Interstitial	Small	Yes	No	Moderate	No
19	30	10	Interstitial		Intermediate	Yes	Prominent	Moderate	No
20	40	10	Interstitial	Sinusoidal	Small	Rare	No	Moderate	No
21	80	90	Diffuse		Large	Yes	Prominent	Moderate	No
22	95	70	Interstitial		Intermediate-to-large	Yes	Prominent	Moderate	No
23	20	83	Interstitial	Sinusoidal	Intermediate	Yes	Prominent	Moderate	No

BM bone marrow
^aFollow up bone marrow shows increased number of large cells with irregular nuclei, nuclear clefts and prominent nucleoli, more open chromatin. Flow shows increased population of large cells

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