Table 4 Cytogenetic and molecular findings in 23 patients with hairy cell leukemia-variant
Case # | Karyotypea | FISH | TP53 mutation | IGH | SHM, %/VH used | BRAF | MAP2K1 mutation | |
|---|---|---|---|---|---|---|---|---|
del[17p] | ATM | |||||||
1 | 46,XX[20] | NA | NA | NA | POS | NEG, >98/VH4-34 | NA | NEG |
2 | 46,XX,ider[20](q10)del[20](q11.2q13.3)[20] | NA | NA | NEG | POS | NA | NA | NEG |
3 | 47,XY,del[7](q22q34),add[12](p13), + mar[12]/46,XY[8] | NEG | NA | NEG | POS | NEG/ VH4-34 | NEG | NEG |
4 | 45,X,-Y,−9,del[11](q13q23), + 12,add[17](p11.2)[12]/46,XY[8]. | POS | POS | NA | POS | NEG/NA | NA | NEG |
5 | 44,X,-X,der(3;17)(p10;q10),der[7]t(7;13)(q36;q11),−13, del[18](q21.1q22), + r[8]/ 46,XX[22] | POS | NEG | NA | NA | NA | NA | NA |
6 | 43–46,X,-Y, del[3](p12p26),del[8](p11.2p23),del[10](p12p15), der[16]t(16;17)(q11.2;q12),−17,−18,add[18](q23), + 1–2mar[cp9] /46,XY[11] | POS | NEG | NA | POS | NEG, >98 /VH3-48 | NA | c.362T>A p.C121S |
7 | 46,XY,t(5;7)(p15.3;q22)[4] /46,XY[15] | NEG | NEG | NA | POS | NEG/NA | NA | NEG |
8 | 46,XY[20] | NEG | NEG | NA | POS | NA | NA | NEG |
9 | 46,XY[20] | NEG | POS | NA | POS | POS, 97.3/VH7 | NEG | NA |
10 | 46,XY[20] | NEG | NEG | NA | POS | NA | NA | NA |
11 | 47,XX, + 15[4]/46,XX[16] | NEG | NEG | NA | POS | POS, 97.3/NA | NA | NA |
12 | 45,X,-Y[13]/46,XY[7] | NA | NA | NA | POS | NEG/NA | NEG | NEG |
13 | 46,XY,t(2;7)(p11.2;q22),add[14](p11.2) [12]/ 46,XY[8] | NA | NA | NA | NA | NA | NEG | NEG |
14 | 46,XY[20] | NEG | NEG | NEG | NA | NA | NEG | NEG |
15 | 46,XY,del[14](q22)[8], 46,sl,add[7](p15)[2], 46,sdl,del[11](q22q23)[3], 46,XY[7] | NA | NA | NA | POS | NEG, >98/VH1-69 | NEG | NEG |
16 | NA | NA | NA | NA | NEG | POS, 96/VH 3-9 | NEG | NEG |
17 | NA | NA | NA | NA | NA | NA | NA | NA |
18 | NA | NA | NA | NA | NA | NA | NA | NA |
19 | NA | NA | NA | NA | NA | NA | NA | NA |
20 | NA | NA | NA | NA | NA | NA | NA | NA |
21 | NA | NA | NA | NA | NA | NA | NA | NA |
22 | 45,X,-Y[9]/46,XY[11] | POS | NA | NA | NA | NA | NEG | NEG |
23 | 42,X,-Y,−2,−6,der[7]t(7;14;19)(q22;q31;q13.3) del[7](q32), del[10](q22q24), del[12](q13q24), add[13](p13), der[14]t(7;14;19), add[17](p13), add[17](q22),−18,der[19]t(7;14;19), + 2mar[5]/ 42,idem,del[1](q21q25),del[8](p21p23)[15] | POS | NA | NA | POS | POS, 94.6/VH3-23 | NEG | NEG |
