Table 6 Hairy cell leukemia-variant characteristics of the present study in comparison with previously published series in the literature
NIH Research groupa | UK Research groupa | |||||||
|---|---|---|---|---|---|---|---|---|
Study | Present Study | ref. [4] | ref. [7] | ref. [25] | ref. [32] | ref. [17] | ref. [5] | ref. [8] |
Study period | 2001–2017 | 2000–2003 | NA | 2001–2008 | NA | 1982–1990 | 1983–2008 | 1983–2007 |
Number of cases | 23 | 10 | 11 | 20 | 24 | 17 | 35 | 35 |
BM material studied, n | 23 BM | 9 BM | BM or PB | PB or BM | NA | 5 BM | 1 BM | 14 BM |
Age, y (range) | 70 (50–89) | 78 (55–93) | 67 (51–85) | 54.8 | NA | 70 (48–92) | 73 (42–90) | 65 (40–98) |
M/F (ratio) | 16/7 (2.3:1) | 8/2 (4:1) | 5/6 (0.8:1) | Similar to HCLc (74:8) | NA | 10/7(1.4:1) | 23/12(1.9:1) | 29/6 (4.8:1) |
WBC, median, (range) ×109/L | 22.0 (22–74) | 30 (3–102) | NA (2–55) | 11.3 (NA) | NA | 116 (15–482) | 30 (7.2–355) | 74.9 (1.8–839) |
Ly, mean/ median(range) ×109/L | 18.6 (1.3–72) | 18 (0.9–90.6) | NA | NA | NA | NA | NA | NA |
Mo, mean/ median (range) ×109/L | 1.76/0.63 (0.1–10.8) | 0.65 (0.1–3.9) | NA | NA | NA | 2.0 (NA) | NA | NA |
HGB, median, (range) g/dL | 11.6 (6.7–16.2) | 12.2 (9.1–15.6) | NA | 13.2(NA) | NA | NA (7–14.5) | 11.0 (7.0–14.1) | NA |
PLT, mean/ median, (range) ×109/L | 112/104(21–295) | 122 (71–245) | NA | 135 (NA) | NA | NA (25–416) | 112.5 (25–416) | NA |
BM involvement, % | 50% (10–90) | NA (10–90) | 35% (3–85) | NA | NA | NA | NA | NA |
Pattern of BM involvement | Interstitial and sinusoidal | Interstitial and sinusoidal | NA | NA | NA | NA | NA | NA |
MAP2K mutations | 1/14 (7%) | NA | 1/11 (9%) | NA | 10/24 (42%) | NA | NA | NA |
Median OS, m | 89.2 | NA | NA | >104 (8.79 y) | NA | NA | NA | NA |
5-year OS, % | 84% | NA | NA | NA | NA | NA | 58% | NA |
