Fig. 1
Bladder tumors and matched lymph-node metastases show high subtype concordance with the exception of tumors of the Basal/Squamous subtype. Each row shows data for one patient. a Molecular subtype classification using immunohistochemistry. The first column shows immunohistochemistry-subtype of primary tumors, the second column of lymph-node metastases, and for two cases a second metastasis is included in the third column. Cases where both the primary tumors and lymph-node metastases were investigated by full section are marked with a star. Cases with marked subtype heterogeneity in full section are indicated with split boxes colored according to the observed subtypes. b Molecular subtype classification by co-clustering of gene expression data. Each box represents the same sample as shown in a. Gray boxes indicate that gene expression data were not available. c Each box represents one mutation, color coded according to its status as shared or private. Gene symbols for 1–2 selected shared mutations (left) and for all private mutations (right) are shown. MIBC muscle-invasive bladder cancer, LNM lymph-node metastasis, ITH intra-tumor heterogeneity
