Table 1 Overview of studies on chromosome 16 changes in columnar cell lesions of the breast
Chromosomal arm | Author | Method | DNA marker | Location | Type of CCL | Gains (G) /losses (L) | Frequency (%) | Absolute numbers |
|---|---|---|---|---|---|---|---|---|
16p | Simpson et al. [6] | CGH | CCL without atypia | G | 16% | 4/25 | ||
Simpson et al. [6] | CGH | CCL with atypia | G | 20% | 2/10 | |||
16q | Simpson et al. [6] | CGH | CCL without atypia | L | 32% | 8/25 | ||
Go et al. [25] | FISH | 16q12.3–13; 16q22.1; 16q23.2 | CCL without atypia | Heteroz del | 0% | 0/19 | ||
Ellsworth et al. [24] | LOH | 16q11.2– 22.1 | CCL with/without atypia | 7% | 3/42 | |||
Ellsworth et al. [24] | LOH | 16q22.3– 24.3 | CCL with/without atypia | 5% | 2/42 | |||
Moinfar et al. [5] | LOH | D16S518 | 16q23.1–24.2 | CCL with atypia | 33% | 2/6 | ||
Moinfar et al. [5] | LOH | D16S402 | 16q24.2 | CCL with atypia | 27% | 3/11 | ||
Aulmann et al. [23] | LOH | D16S539 | 16q24 | CCL with atypia | 27% | 3/11 | ||
Aulmann et al. [23] | LOH | D16S2624 | 16q22.3 | CCL with atypia | 46% | 11/24 | ||
Simpson et al. [6] | CGH | CCL with atypia | L | 40% | 4/10 | |||
Stacher et al. [26] | aCGH | CCL with atypia | L | 70% | 7/10 | |||
Go et al. [25] | FISH | 16q12.3–13 | CCL with atypia | Heteroz del | 20% | 2/10 | ||
Go et al. [25] | FISH | 16q22.1 | CCL with atypia | Heteroz del | 10% | 1/10 | ||
Go et al. [25] | FISH | 16q23.2 | CCL with atypia | Heteroz del | 10% | 1/10 |
