Fig. 1 | Modern Pathology

Fig. 1

From: HPV E4 expression and DNA hypermethylation of CADM1, MAL, and miR124-2 genes in cervical cancer and precursor lesions

Fig. 1

Examples of E4 protein expression and hypermethylation of CADM1, MAL, or miR124-2 according to cervical intraepithelial neoplasia (CIN) grading and immunoscore grading. a No dysplasia; basal Ki-67 positivity and no p16 ; no E4 positivity and no hypermethylation for genes CADM1, MAL, or miR124-2. b CIN1; parabasal Ki-67 positivity, patchy p16 positivity; extensive E4 expression and no hypermethylation for genes CADM1, MAL, or miR124-2. c CIN2; full thickness Ki-67 positivity and p16 positivity; extensive E4 expression and no hypermethylation for genes CADM1, MAL, or miR124-2. d CIN3; full thickness Ki-67 positivity and p16 positivity; no E4 expression and positive hypermethylation for genes CADM1, MAL, or miR124-2. e CIN3; full thickness Ki-67 positivity and p16 positivity; extensive E4 expression and negative hypermethylation for genes CADM1, MAL, or miR124-2

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