Table 4 Clinico-pathological characteristics of the three cases with true tumor cell staining for PD-L1

Patient	Group	Age/sex	Tumor site	Histology	TILs/HPF	PD-L1 IHC % at TSI	PD-L1 IHC % of tumor cell staining^a	MMR IHC	Tumor stage	Treatment	Follow up status
1	MMRd-sporadic	70/M	Right colon	Poorly differentiated	2	70	80	Loss of MLH1/PMS2	T3N0	Surgery alone	NED at 100 months
2	MMRd-sporadic	83/F	Right colon	Medullary carcinoma	67	90	90	Loss of MLH1/PMS2	T3N1a	Surgery alone	Anastomotic recurrence at 24 months, DOD at 36.7 month
3	MMRp-TIL-H	75/M	Right colon	Poorly differentiated	24	50	50	Normal	T3N0	Surgery alone	Died of unrelated cause at 49.25 months

^aCalculated based on the amount of positively stained tumor cells over the total amount of tumor cells
MMRd mismatch repair deficiency, TIL tumor infiltrating lymphocytes, HPF high power field, TII tumor infiltrating immune cells, IHC immunhistochemistry,TSI tumor-stroma interface, MMRp mismatch repair proficient, NED no evidence of disease, DOD died of disease

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