Table 1 Next-generation sequencing determination of mismatch repair deficiency, defined by number of indel events in mononucleotide repeats, compared to immunohistochemistry, defined by loss of nuclear expression of MLH1, MSH2, MSH6, or PMS2

From: Targeted next-generation sequencing in the detection of mismatch repair deficiency in endometrial cancers

  

Immunohistochemistry

 
  

Deficient (protein loss)

Proficient (proteins intact)

Sequencing

Deficient (>2.5 indel/Mb)

47

1

Proficient (<1.5 indel/Mb)

9

190

Indeterminate (1.5–2.5 indel/Mb)

7

5

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