Fig. 5 | Modern Pathology

Fig. 5

From: Aberrant receptor tyrosine kinase signaling in lipofibromatosis: a clinicopathological and molecular genetic study of 20 cases

Fig. 5

a Interphase FISH with probes for 5′ FN1 (green) and 3′ EGF (red) showing fused red and green signals, indicative of an FN1-EGF fusion in case 6. b Chromatogram illustrating the TPR-ROS1 fusion transcript in case 7. c Schematic view of the tyrosine kinases involved in gene fusions in lipofibromatosis. Lollipops indicate the breakpoints, which consistently were close to the kinase domains. d Increased expression of the distal part of GRIA1 as a result of the fusion of EGR1 exon 1 with GRIA1 exon 3 in case 3

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