Fig. 2 | Modern Pathology

Fig. 2

From: Focal Rosai–Dorfman disease coexisting with lymphoma in the same anatomic site: a localized histiocytic proliferation associated with MAPK/ERK pathway activation

Fig. 2

Focal Rosai–Dorfman disease coexisting with classical Hodgkin lymphoma, mixed cellularity (case 8). Lymph node involved by classical Hodgkin lymphoma associated with foci of Rosai–Dorfman disease (pale areas). The abnormal histiocytes satellite around lymphoid nodules (a, 20 × ; b, 100 × ; c, 200 × ). Medium- and high-power magnification show histiocytes with emperipolesis intimately associated with Hodgkin Reed–Sternberg cells (d, 400 × ; e, 1000 × ). Immunostain for S100 protein highlights Rosai–Dorfman histiocytes and provides contrast with negatively outlined lymphocytes and Hodgkin Reed–Sternberg cells (f, arrows, 1000 × )

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