Fig. 6

Proposal of a two-step pathological approach in localized stages II and III pediatric adrenal cortical neoplasms to consider need of adjuvant systemic therapy. In step 1, items in bold are supplied or confirmed by pathological study. R0: microscopically complete initial surgical resection; R1: initial surgical resection with microscopic residuals or tumor spillage; R2: initial surgical resection with macroscopic residuals