Table 4 Outcomes according to pathologic criteria after review (univariate analysis)
PFS | OS | |||||
|---|---|---|---|---|---|---|
Criteriaa | n | HR (95% CI) | p-Value | n | HR (95% CI) | p-Value |
Weight (g) | ||||||
[2.9–100.0] | 54 | 1 | 54 | 1 | ||
[100.0–1870.0] | 34 | 31.0 [4.09; 235.3] | < 0.001 | 34 | 24.4 [3.17; 188] | 0.002 |
Size (cm) | ||||||
[2.0–10.5] | 73 | 1 | 73 | 1 | ||
[10.5–22.0] | 17 | 13.3 [4.66; 37.7] | < 0.001 | 17 | 10.5 [3.37; 32.8] | < 0.001 |
Extension into periadrenal soft tissues | 12 | 9.75 [3.56; 26.7] | < 0.001 | 12 | 15.5 [4.80; 50.3] | < 0.001 |
Extension into adjacent organs | 2 | 31.9 [5.25; 193] | < 0.001 | 2 | 17.6 [3.73; 83.6] | < 0.001 |
Vena cava invasion | 6 | 2.78 [0.63; 12.3] | 0.179 | 6 | 3.87 [0.83; 18.0] | 0.084 |
Vascular invasion | 24 | 5.62 [1.84; 17.2] | 0.003 | 24 | 4.93 [1.38; 17.5] | 0,014 |
Capsular invasion | 22 | 6.47 [2.11; 19.8] | 0.001 | 22 | 15.7 [3.34; 74.3] | < 0.001 |
Mitotic count > 15/20 HPF | 21 | 3.26 [1.21; 8.76] | 0.019 | 21 | 3.41 [1.14; 10.2] | 0.028 |
Atypical mitotic figures | 55 | 3.16 [0.89; 11.2] | 0.075 | 55 | 3.98 [0.87; 18.2] | 0.075 |
Pre-operative rupture changes | 10 | 4.61 [1.35; 15.8] | 0.015 | 10 | 3.38 [0.84; 13.7] | 0.087 |
Wieneke score | ||||||
< 3 (n = 60) | 1 | 1 | ||||
= 3 (n = 11) | 22.7 [2.54; 203] | 0.002 | 8.28 [1.38; 49.6] | 0.003 | ||
> 3 (n = 24) | 41.3 [5.32; 320] | 14.6 [3.15; 68.4] | ||||
