Fig. 4 | Modern Pathology

Fig. 4

From: Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma

Fig. 4

Representative H&E and immunophenotype of the sarcomas with novel fusions. a–c Soft tissue myoepithelial tumor (TRPS1-PLAG1) shows epithelioid to plasmacytoid cells in aggregates in a myxoid background with scattered areas showing distinct gland formation. The tumor is strongly and diffusely positive for Pan-CK and S100 by IHC. (a: ×200, bc: ×400) d, e Perivascular epithelioid cell tumor (PEComa, VCP-TFE3) in the pancreas. The tumor is well circumscribed at the periphery and demonstrates large polygonal cells with eosinophilic to clear cytoplasm. (d: ×200, e: ×400) f, g Pseudomyogenic hemangioendothelioma (ACTB-FOSB) composed of spindle cells with moderate amount of eosinophilic cytoplasm and is positive for ERG immunostain. (×400). h–j Rhabdomyosarcoma (FUS-TFCP2) arising in the maxillary gingiva demonstrating monomorphic oval to spindle cells in an inflammatory background. The tumor is strongly positive for  MYOD1 by IHC. (h: ×200, i j: ×400)

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