Fig. 6 | Modern Pathology

Fig. 6

From: Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma

Fig. 6

Representative H&E images a, b of the metastatic sarcoma-not otherwise specified to the lung with unknown primary site. The tumor shows a mixture of spindled to epithelioid cells in a whorling and nodular growth pattern. c Schematic diagrams of the novel fusion MYLK-BRAF joining MYLK exon24 to BRAF exon10. The BRAF protein kinase domain is included in the predicted fusion protein. (Magnification: a: ×200, b: ×400). Protein domain info taken from http://www.uniprot.org/. Ig_l immunoglobulin-like domain. FN3 Fibronectin type-III domain

Back to article page