Table 2 Patient and tumor characteristics of matched interval and non-interval colorectal cancers (CRC)

From: Clinicopathologic and genetic characteristics of interval colorectal carcinomas favor origin from missed or incompletely excised precursors

Featureb

Interval CRC N = 51 (col %)

Matched non-interval CRCa N = 51 (col %)

P (matched comparison)

Tumor size at diagnosis (cm)

Median (±IQR)

3.5 cm (2.5)

3.7 cm (2.3)

0.97

T stage

≤T2

17 (33)

16 (31)

0.55

 

>T2

31 (61)

36 (71)

 

N stage

0

26 (51)

28 (55)

0.84

 

1

10 (20)

17 (33)

 
 

2 or above

8 (16)

5 (10)

 

Metastasis at diagnosis

No

45 (88)

48 (94)

0.33

 

Yes

6 (12)

3 (6)

 

Tumor grade

Low

38 (75)

34 (67)

0.39

 

High

13 (25)

17 (33)

 

Lymphovascular invasion

No

36 (71)

32 (63)

0.35

 

Yes

12 (24)

18 (35)

 

Mucinous differentiation

No

35 (69)

41 (80)

0.59

 

Yes

12 (24)

10 (20)

 

Medullary differentiation

No

45 (88)

49 (96)

0.57

 

Yes

2 (4)

1 (2)

 

Signet-ring cell differentiation

No

44 (86)

49 (96)

0.66

 

Yes

3 (6)

2 (4)

 

Loss of MMR IHC expressionc

No

41 (80)

41 (80)

1.00

 

Yes

10 (20)

10 (20)

 

Current folate user at time of diagnosis

No

47 (92)

50 (98)

0.57

 

Yes

2 (4)

1 (2)

 

Current aspirin user at time of diagnosis

No

32 (63)

36 (71)

0.40

 

Yes

18 (35)

15 (29)

 

Smoker at time of diagnosis

No

26 (51)

25 (49)

1.00

 

Past

21 (41)

15 (29)

 
 

Current

1 (2)

7 (14)

 
  1. aMatched on 10-year age group, tumor location, and gender
  2. bColumn percentages may not add up to 100% due to missing information or inability to assess in biopsy samples
  3. cAssessed by 4-antibody panel: MLH1, PMS2, MSH2, MSH6