Table 1 Correlation between legumain expression with different clinicopathological parameters in the pure DCIS cohort
From: Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ
Clinicopathological parameters | Legumain expression in tumor epithelial cells | χ2 (p-value) | Legumain expression in stromal fibroblasts | χ2 (p value) | ||
|---|---|---|---|---|---|---|
Low (N = 359) No. (%) | High (N = 105) No. (%) | Low (N = 259) No. (%) | High (N = 205) No. (%) | |||
Age (years) | ||||||
≤50 | 88 (25) | 27 (24) | 0.1 (0.802) | 62 (24) | 53 (26) | 0.3 (0.635) |
>50 | 271 (75) | 78 (76) | 197 (76) | 152 (74) | ||
Presentation | ||||||
Screening | 177 (49) | 48 (46) | 0.4 (0.517) | 134 (51) | 91 (44) | 2.5 (0.116) |
Symptomatic | 182 (51) | 57 (54) | 125 (49) | 114 (56) | ||
DCIS size (mm) | ||||||
<16 | 112 (31) | 22 (21) | 4.8 (0.092) | 77 (30) | 57 (28) | 0.2 (0.927) |
16–40 | 148 (41) | 45 (43) | 107 (41) | 86 (42) | ||
>40 | 98 (28) | 37 (36) | 75 (29) | 60 (30) | ||
Nuclear grade | ||||||
Low | 51 (14) | 8 (8) | 19.2 (<0.0001) | 39 (15) | 20 (10) | 12.6 (0.002) |
Moderate | 113 (32) | 15 (14) | 84 (32) | 44 (21) | ||
High | 195 (54) | 82 (78) | 136 (53) | 141 (69) | ||
Comedo necrosis | ||||||
Yes | 226 (63) | 80 (76) | 6.3 (0.012) | 160 (62) | 59 (30) | 4.5 (0.033) |
No | 133 (37) | 25 (23) | 99 (38) | 146 (70) | ||
Estrogen receptor | ||||||
Negative | 62 (19) | 54 (54) | 46.8 (<0.0001) | 42 (18) | 74 (39) | 23.3 (<0.0001) |
Positive | 266 (81) | 47 (46) | 195 (82) | 118 (61) | ||
Progesterone receptor | ||||||
Negative | 114 (34) | 67 (66) | 31.3 (<0.0001) | 76 (32) | 105 (55) | 23.5 (<0.0001) |
Positive | 217 (66) | 35 (34) | 165 (68) | 87 (45) | ||
HER2 status | ||||||
Negative | 256 (79) | 60 (63) | 9.9 (0.002) | 190 (80) | 126 (69) | 6.6 (0.010) |
Positive | 68 (21) | 35 (37) | 47 (20) | 56 (31) | ||
Proliferation index (Ki-67) | ||||||
High | 59 (20) | 36 (37) | 11.7 (0.001) | 31 (14) | 64 (35) | 23.3 (<0.0001) |
Low | 240 (80) | 62 (63) | 184 (86) | 118 (65) | ||
Molecular classes | ||||||
Luminal A | 160 (58) | 22 (24) | 46.4 (< 0.0001) | 127 (63) | 55 (33) | 36.3 (<0.0001) |
Luminal B | 61 (22) | 18 (20) | 35 (18) | 44 (26) | ||
HER2-enriched | 25 (9) | 22 (25) | 19 (10) | 28 (17) | ||
Triple-negative | 29 (11) | 28 (31) | 18 (9) | 39 (24) | ||
Tumor-infiltrating lymphocytes | ||||||
Dense | 123 (44) | 55 (63) | 9.6 (0.002) | 72 (36) | 106 (63) | 27.7 (<0.0001) |
Sparse | 159 (56) | 33 (37) | 130 (64) | 62 (37) | ||
DCIS type* | ||||||
Pure DCIS | 359 (75) | 105 (61) | 11.7 (0.001) | 259 (91) | 205 (56) | 95.6 (<0.0001) |
DCIS with invasive breast cancer | 123 (25) | 68 (39) | 27 (9) | 164 (44) | ||
