Table 2 Multivariate survival analysis (Cox regression model) of variables predicting outcome in terms of ipsilateral local recurrence in patients treated by breast-conserving surgery in pure DCIS cohort
From: Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ
Parameters | HR | 95% CI | p value | |
|---|---|---|---|---|
Lower | Upper | |||
(A) All recurrences | ||||
High legumain expression | 3.5 | 1.8 | 4.9 | 0.0003 |
Patient age | 1.4 | 1.2 | 2.6 | 0.019 |
DCIS presentation | 1.8 | 0.8 | 3.8 | 0.103 |
DCIS size | 0.8 | 0.5 | 1.3 | 0.297 |
DCIS nuclear grade | 1.5 | 0.9 | 2.6 | 0.148 |
Comedo necrosis | 0.7 | 0.3 | 1.4 | 0.268 |
Molecular classes | 0.8 | 0.6 | 1.2 | 0.260 |
Radiotherapy | 0.3 | 0.1 | 0.9 | 0.045 |
Margin status | 0.8 | 0.4 | 1.3 | 0.752 |
(B) Invasive recurrence | ||||
High legumain expression | 3.4 | 1.8 | 8.3 | 0.002 |
Patient age | 1.5 | 0.7 | 2.3 | 0.129 |
DCIS presentation | 1.4 | 0.5 | 3.6 | 0.511 |
DCIS size | 1.2 | 0.6 | 2.4 | 0.688 |
DCIS nuclear grade | 1.4 | 0.7 | 2.9 | 0.349 |
Comedo necrosis | 1.1 | 0.4 | 2.8 | 0.912 |
Molecular classes | 0.5 | 0.3 | 0.9 | 0.027 |
Radiotherapy | 0.2 | 0.1 | 0.9 | 0.040 |
Margin status | 0.9 | 0.4 | 1.9 | 0.813 |
