Table 6 Analysis of 22C3 tumor proportion score (TPS) groups
Tumor typea | Search parameter | Number of cases | Average age, years | M:F | QNS % | Negative ( < 1%) | Expressed (1-49%) | Highly expressed ( = > 50%) |
|---|---|---|---|---|---|---|---|---|
All cases | 52,585 | 68.9 | 51:49 | 3.6 | 33.1 | 33.9 | 29.5 | |
Brain | “astrocytoma” or “glioblastoma” or “gbm” | 82 | 56.4 | 49:33 | 1.2 | 42.7 | 37.8 | 18.3 |
Breast | “breast” or “lobular” or [“ductal” not “pancreatic”] | 737 | 61.3 | 0:737 | 3.7 | 58.2 | 27.5 | 10.6 |
Colon | “colon” or “colonic” or “sigmoid” or “rectum” | 1142 | 64.3 | 321:521 | 1.9 | 66.6 | 26.2 | 5.3 |
Endometrial | “endometrium” or “endometrial” or “uterus” | 258 | 63.5 | 0:258 | 3.1 | 54.7 | 38.0 | 4.3 |
Esophageal | “esophageal” or “esophagus” or “GEJ” or “gastroesophageal” | 384 | 66.8 | 288:96 | 2.9 | 47.9 | 36.7 | 12.5 |
Gastric | “gastric” or “stomach” or “pyloric” or “antrum” or “cardia” | 545 | 64.5 | 305:240 | 3.9 | 45.9 | 30.3 | 20.0 |
Gastrointestinal stromal tumor | [“gastrointestinal” and “stroma”] or “GIST” | 42 | 65.0 | 24:18 | 2.4 | 50.0 | 45.2 | 2.4 |
Hodgkin lymphoma | “Hodgkin” and “lymphoma” not [“NHL” or “non”] | 12 | 58.8 | 5:7 | 8.3 | 41.7 | 16.7 | 33.3 |
Lung | [“lung” and “origin”] or [“lung” and “primary”] or [“non” and “small” and “cell”] or [“lepidic”] or [“pulmonary” and “origin”] or [“bronchogenic”] or [“NSCLC”] | 1695 | 69.7 | 819:876 | 3.9 | 25.9 | 33.7 | 36.5 |
Melanoma | “melanoma” | 555 | 66.8 | 343:212 | 3.2 | 40.7 | 42.0 | 14.0 |
Mesothelioma | “mesothelioma” | 77 | 71.6 | 55:22 | 3.9 | 37.7 | 42.9 | 15.6 |
Mycosis fungoides | “mf” or “mycosis” or “fungoides” | 23 | 58.9 | 11:12 | 0 | 13.0 | 34.8 | 52.1 |
Neuroendocrine | “neuroendocrine” or “merkel” or “carcinoid” | 268 | 67.2 | 150:118 | 2.6 | 62.3 | 28.4 | 6.7 |
Ovary | “ovary” or “ovarian” | 256 | 62.3 | 0:256 | 2.0 | 61.3 | 33.2 | 3.5 |
Pancreas | “pancreas” or “pancreatic” or “ampulla” | 286 | 65.0 | 153:133 | 2.8 | 54.6 | 31.8 | 10.8 |
Prostate | “prostate” and “prostatic” | 193 | 72.4 | 193:0 | 3.1 | 63.2 | 23.8 | 9.8 |
Renal | “kidney” or “renal” | 246 | 66.6 | 142:104 | 3.7 | 45.1 | 30.1 | 21.1 |
Sarcoma | “sarcoma” | 140 | 63.8 | 69:71 | 2.1 | 40.7 | 23.6 | 33.6 |
Thymoma | “thymoma” | 9 | 57.2 | 3:6 | 11.1 | 22.2 | 22.2 | 44.4 |
Thyroid | “thyroid” | 68 | 61.3 | 18:50 | 4.4 | 49.0 | 20.6 | 26.5 |
Urothelial | “bladder” or “urothelial” or “transitional” | 273 | 70.9 | 177:96 | 2.9 | 46.5 | 31.9 | 18.7 |
Vulva or vagina | “vulva” or “vagina” | 85 | 64.4 | 0:85 | 2.3 | 44.7 | 31.8 | 21.2 |
Adenocarcinoma | “adenocarcinoma” | 9575 | 69.1 | 4302:5273 | 3.2 | 33.7 | 34.5 | 28.6 |
Poorly differentiated adenocarcinoma | [“poorly” and “differentiated”] and “adenocarcinoma” | 974 | 67.8 | 486:488 | 2.5 | 22.1 | 27.2 | 48.3 |
Moderately differentiated adenocarcinoma | [“moderately” and “differentiated”] and “adenocarcinoma” | 676 | 69.1 | 304:372 | 2.5 | 36.8 | 38.6 | 22.0 |
Well-differentiated adenocarcinoma | [“well” and “differentiated”] and “adenocarcinoma” | 278 | 71.5 | 114:164 | 4.7 | 49.6 | 38.1 | 7.6 |
Mucinous adenocarcinoma | “mucinous” and “adenocarcinoma” | 226 | 69.7 | 111:115 | 3.5 | 51.3 | 34.1 | 11.1 |
Squamous cell carcinoma | “squamous” or “SCC” or “SCCA” | 3102 | 70.5 | 1905:1197 | 2.3 | 26.4 | 40.8 | 30.5 |
Poorly differentiated squamous cell carcinoma | [“poorly” and “differentiated”] and “squamous” or “SCC” or “SCCA” | 575 | 70.2 | 348:227 | 2.7 | 24.7 | 37.0 | 36.0 |
Moderately differentiated squamous cell carcinoma | [“moderately” and “differentiated”] and “squamous” or “SCC” or “SCCA” | 508 | 71.6 | 312:196 | 0.6 | 24.2 | 44.3 | 30.9 |
Well-differentiated squamous cell carcinoma | [“well” and “differentiated”] and “squamous” or “SCC” or “SCCA” | 71 | 68.6 | 42:29 | 1.4 | 16.9 | 54.9 | 26.8 |
Adenosquamous | “adenosquamous” | 82 | 73.5 | 48:34 | 0 | 20.7 | 35.4 | 43.9 |
Metastatic | “metastatic” | 3933 | 67.5 | 1944:1989 | 2.6 | 35.9 | 30.8 | 30.7 |
Pleural fluid | [“pleural” and “fluid”] or [“pleural” and effusion”] | 2105 | 72.1 | 1025:1080 | 3.1 | 29.6 | 32.6 | 34.6 |
Pericardial fluid | “pericardial” and “fluid” | 44 | 66.5 | 15:29 | 0 | 0 | 0 | 100 |
Bone | “bone” | 2275 | 68.3 | 1246:1029 | 3.3 | 40.7 | 29.2 | 26.7 |
Metastases in brain | “brain” and “metastatic” | 47 | 62.9 | 18:29 | 2.1 | 42.6 | 23.4 | 31.9 |
Adrenal | “adrenal” | 549 | 67.7 | 307:242 | 3.6 | 27.5 | 33.9 | 35.0 |
