Fig. 1
Patterns of TIM-3 expression in endometrial carcinomas. TIM-3 was expressed in tumor cells (a, b) and in tumor-associated lymphocytes (c, d). Tumoral staining was considered positive when clear full or partial membranous expression was identified. Case a depicts a tumor with diffuse tumoral expression as well as scattered positive tumor-associated immune cells. Case b shows patchy tumoral positivity without a significant contribution of positive immune cells in this field (scattered positive tumor-associated lymphocytes were present elsewhere). Cases c and d show no tumoral expression (the apical blush depicted in some cells in case c was not considered positive), but focal (c) and robust (d) associated immune cell expression
