Fig. 2
Mismatch repair status and TIM-3. High levels of tumoral TIM-3 expression were most often identified in endometrial cancers with MLH1-hypermethylation, like the case in (a, b). This case demonstrated tumoral staining in the majority of tumor cells as well as moderate associated immune cell expression. The MSH6-deficient case illustrated in (c, d) demonstrated patchy tumoral positivity with a more robust TIM-3 positive immune cell infiltrate. In contrast, the mismatch repair-intact endometrial cancer shown in (e, f) was entirely negative for TIM-3 within the tumor cells and showed only rare positive associated lymphocytes
