Fig. 3
TIM-3 in high-grade endometrial carcinomas. Tumoral TIM-3 expression was overall more common among intermediate and high-grade cancers when compared to low-grade tumors, with the most dramatic trend observed in the mismatch repair-intact subgroup. The dedifferentiated grade 3 MLH1-hypermethylated cancer depicted in (a, b) showed patchy positivity concentrated in areas of solid architecture, while the MSH6-deficient dedifferentiated tumor in (c, d) showed tumoral expression concentrated at the tumor-stroma interface. The mismatch repair-intact carcinosarcoma illustrated in (e, f) was among the most strongly positive cases in the series, with regions of widespread expression concentrated in the poorly-differentiated epithelial components of the tumor
