Fig. 5

TIM-3 expression in carcinosarcomas and de-differentiated carcinomas. Both carcinosarcomas in the series demonstrated TIM-3 expression predominantly in the epithelial component of the tumor, as is illustrated in case (a, b). De-differentiated carcinomas, in contrast, showed variable expression patterns, with some showing positivity in both well-defined glands and poorly-differentiated elements, and others, like the tumor depicted in (c, d), showing little expression in the poorly-differentiated component but patchy expression in the adjacent well-formed glands