Table 1 Clinical and histopathological characteristics of all parathyroid tumors stained for parafibromin
Diagnosis | No. of cases/patients selected for immunohistochemistry | Male/female | Median age (range) | Median tumor weight in mg (range) | Median Ki-67 index (%) (range) | No. of IHC informative cases/patients | Positive staining | Partial loss | Complete negative staining | Loss of nucleolar staining |
|---|---|---|---|---|---|---|---|---|---|---|
Adenoma | 226/223 | 79/144 | 59 (16–88) | 1515 (30–21200) | 1.7 (0.1–11) | 182/179 | 168 | 8 | 2 | 4 |
Atypical adenoma | 61/60 | 28/32 | 61.5 (19–85) | 1800 (230–32000) | 5.3 (0.6–27) | 46/45 | 16 | 25 | 2 | 3 |
Carcinoma | 10/10 | 7/3 | 59 (36–71) | 1803 (517–14070) | 5 (0.1–20) | 10/10 | 3 | 5 | 2 | 0 |
In total | 297/293 | 114/179 | – | – | – | 238/234 | 187 | 38 | 6 | 7 |
