Table 2 Top six equivocal histological parameters found in the cohort and correlations to parafibromin immunohistochemistry
Various histological parameters coupled to parafibromin staining outcomes | |||||||
|---|---|---|---|---|---|---|---|
Equivocal histological parameter | Total number of tumors with this phenotype | of which X cases with aberrant parafibromin staining | of which X cases with positive parafibromin staining | of which X cases with uninformative parafibromin staining | of which X cases with a diagnosis of atypical adenoma | of which X cases with a diagnosis of carcinoma | of which X cases with a diagnosis of adenoma |
Marked tumor weight | 146 | 26 | 92 | 28 | 29 | 5 | 112 |
Fibrosis | 77 | 18 | 43 | 16 | 31 | 0 | 46 |
Marked pleomorphism | 58 | 10 | 36 | 12 | 16 | 0 | 42 |
Unclear relation to capsule | 57 | 17 | 30 | 10 | 24 | 0 | 33 |
Trabecular growth pattern | 49 | 15 | 23 | 11 | 24 | 6 | 19 |
Cystic growth pattern | 49 | 7 | 33 | 9 | 10 | 0 | 39 |
Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) | |||||
|---|---|---|---|---|---|---|---|---|
Equivocal histological parameter | Predicting aberrant parafibromin staining | Predicting atypical adenoma or carcinoma | Predicting aberrant parafibromin staining | Predicting atypical adenoma or carcinoma | Predicting aberrant parafibromin staining | Predicting atypical adenoma or carcinoma | Predicting aberrant parafibromin staining | Predicting atypical adenoma or carcinoma |
Marked tumor weight | 51% | 48% | 51% | 50% | 22% | 23% | 79% | 75% |
Fibrosis | 35% | 44% | 77% | 80% | 30% | 40% | 81% | 82% |
Marked pleomorphism | 20% | 23% | 81% | 81% | 22% | 28% | 79% | 77% |
Unclear relation to capsule | 33% | 34% | 84% | 85% | 36% | 42% | 82% | 80% |
Trabecular growth pattern | 29% | 42% | 88% | 92% | 39% | 61% | 82% | 83% |
Cystic growth pattern | 14% | 14% | 82% | 83% | 18% | 20% | 78% | 75% |
