Table 3 Sensitivity, specificity and positive/negative predictive values of parafibromin to detect atypia or malignant tumors
Parafibromin immunohistochemistry | Atypical adenoma or carcinoma vs. adenoma | Atypical adenoma or carcinoma vs. adenoma | ||||||
|---|---|---|---|---|---|---|---|---|
Sensitivity | Specificity | Positive predictive value (%) | Negative predictive value (%) | Sensitivity | Specificity | Positive predictive value (%) | Negative predictive value (%) | |
Completely negative, partial loss or nucleolar loss vs. positive staining | 66% | 92% | 73% | 90% | 70% | 81% | 14% | 98% |
Completely negative or partial loss vs. positive staining (excluding nucleolar) | 64% | 97% | 85% | 90% | 70% | 85% | 18% | 98% |
