Fig. 2

a Distribution of Ki67 index scoring on the C1 and C2 tissue microarray. C2 tumors show significantly higher proliferation index than C1 tumors. Also, C1 tumors show a significant increase in proliferation from in situ to invasive disease which is not seen in C2 tumors. b Likewise positivity for p53 staining was significantly higher in C2 lesions overall and showed an increase from in situ to invasive disease only within C1 lesions. c Studying mesenchymal Vimentin as a marker of epithelial–mesenchymal transition within this cohort, expression increased significantly from in situ to invasive disease in C1 tumors only