Fig. 3 | Modern Pathology

Fig. 3

From: In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth—a clinically relevant distinction

Fig. 3

Representative staining of in situ and invasive 1 mm diameter cores from the early adenocarcinoma LATTICe-A tissue microarray, for Ki67, p53, and Vimentin. These example cases show Ki67 which is of higher fraction in the invasive component for Ki67 staining. In the cores stained for p53 the in situ core is negative, with positivity in the invasive core. Vimentin expression is seen in only the stroma and alveolar macrophages in the in situ core, with tumor cell expression identified in the invasive core

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