Table 1 Clinical characteristics at the time of biopsy
From: Complement-mediated microangiopathy in IgA nephropathy and IgA vasculitis with nephritis
Microangiopathy absent n = 102 | Microangiopathy present n = 26 | Total n = 128 | p value | |
|---|---|---|---|---|
Diagnosis | 0.126 | |||
IgA nephropathy, n (%) | 81 (79) | 24 (92) | 105 (82) | |
IgA vasculitis with nephritis, n (%) | 21 (21) | 2 (8) | 23 (18) | |
Female patients, n (%) | 32 (31) | 7 (27) | 39 (31) | 0.660 |
Pediatric patients, n (%) | 21 (21) | 1 (4) | 22 (17) | 0.043 |
Age, years | 41.1 ± 22.1 | 45.9 ± 15.6 | 42.1 ± 21.0 | 0.203 |
Clinical thrombotic microangiopathy, n (%) | 0 (0) | 1 (4) | 1 (1) | 0.203 |
Malignant hypertension, n (%) | 2 (2) | 2 (8) | 4 (3) | 0.183 |
Hypertension, n (%) | 50 (49) | 20 (77) | 70 (55) | 0.011 |
Systolic blood pressure (mmHg) | 136.2 ± 25.4 | 153.0 ± 34.1 | 139.7 ± 28.1 | 0.006 |
Diastolic blood pressure (mmHg) | 79.6 ± 15.7 | 93.5 ± 20.7 | 82.5 ± 17.7 | <0.001 |
Number of antihypertensive drugs taken | 0.9 ± 1.1 | 1.4 ± 1.1 | 1.0 ± 1.1 | 0.042 |
Type of antihypertensive drugsa | ||||
None, n (%) | 52 (52) | 7 (27) | 59 (47) | 0.033 |
Angiotensin-converting enzyme inhibitor and/or angiotensin-receptor blocker, n (%) | 34 (34) | 16 (62) | 50 (40) | |
Other, n (%) | 14 (14) | 3 (11) | 17 (13) | |
Use of corticosteroids, n (%) | 42 (41) | 10 (39) | 52 (41) | 0.801 |
Proteinuria (g/day) | 1.93 ± 2.37 | 3.25 ± 2.31 | 2.29 ± 2.41 | 0.035 |
Serum creatinine in adults (mg/dL) | 2.2 ± 2.7 | 2.8 ± 2.4 | 2.4 ± 2.7 | 0.328 |
Serum creatinine in children (mg/dL) | 0.7 ± 0.3 | 0.4 | 0.7 ± 0.3 | 0.423 |
Estimated glomerular filtration rate (mL/min/1.73 m2) | 63.9 ± 41.3 | 37.7 ± 25.3 | 58.6 ± 39.9 | <0.001 |
IgA (g/L) | 3.5 ± 1.6 | 3.5 ± 1.4 | 3.5 ± 1.5 | 0.950 |
Serum IgA: C3 | 3.1 ± 2.0 | 2.8 ± 1.2 | 3.1 ± 1.9 | 0.702 |
Serum C3 (g/L) | 1.2 ± 0.3 | 1.1 ± 0.2 | 1.2 ± 0.3 | 0.425 |
Serum C4 (mg/L) | 265.3 ± 113.7 | 232.3 ± 74.6 | 260.3 ± 108.8 | 0.434 |
