Table 2 Renal biopsy characteristics
From: Complement-mediated microangiopathy in IgA nephropathy and IgA vasculitis with nephritis
Microangiopathy absent n = 102 | Microangiopathy present n = 26 | Total n = 128 | p value | |
|---|---|---|---|---|
Percentage of glomeruli with global sclerosis, mean ± SD | 13 ± 18 | 33 ± 26 | 17 ± 22 | 0.001 |
Mesangial hypercellularity (M1) | 49 (48) | 18 (69) | 67 (52) | 0.053 |
Endocapillary proliferation (E1) | 26 (25) | 11 (42) | 37 (29) | 0.091 |
Segmental glomerulosclerosis (S1) | 41 (40) | 16 (62) | 57 (45) | 0.051 |
Tubular atrophy and interstitial fibrosis (T) | <0.001 | |||
≤25% (T0) | 63 (62) | 8 (31) | 71 (56) | |
26–50% (T1) | 28 (27) | 3 (11) | 31 (24) | |
>50% (T2) | 11 (11) | 15 (58) | 26 (20) | |
Crescents (C) | 0.550 | |||
Absent (C0) | 87 (85) | 24 (92) | 111 (87) | |
1–24% of glomeruli (C1) | 12 (12) | 2 (8) | 14 (11) | |
≥25% of glomeruli (C2) | 3 (3) | 0 (0) | 3 (2) | |
Glomerular necrosis, n (%) | 4 (4) | 0 (0) | 4 (3) | 0.582 |
Arteriolar hyalinosis, n (%) | 29 (28) | 15 (58) | 44 (34) | 0.010 |
Arterial intimal sclerosisa, n (%) | 23 (24) | 21 (81) | 44 (36) | <0.001 |
