Table 3 Complement proteins in biopsies of patients with or without microangiopathy
From: Complement-mediated microangiopathy in IgA nephropathy and IgA vasculitis with nephritis
Microangiopathy absent n = 94 | Microangiopathy present n = 22 | Total n = 116 | p value | |
|---|---|---|---|---|
C4d positive, n (%) | 16 (17) | 17 (77) | 33 (28) | <0.001 |
In glomeruli, n (%) | 14 (15) | 12 (55) | 26 (22) | <0.001 |
In arterioles, n (%) | 5 (5) | 11 (50) | 16 (14) | <0.001 |
C5b-9 positive, n (%) | 44 (47) | 16 (73) | 60 (52) | 0.029 |
In glomeruli, n (%) | 11 (12) | 6 (27) | 17 (15) | 0.063 |
In arterioles, n (%) | 43 (46) | 15 (68) | 58 (50) | 0.058 |
C1q positive, n (%) | 34 (36) | 13 (59) | 47 (41) | 0.049 |
In glomeruli, n (%) | 30 (32) | 10 (46) | 40 (35) | 0.229 |
In arterioles, n (%) | 8 (9) | 6 (27) | 14 (12) | 0.015 |
MBL positive, n (%) | 2 (2) | 0 (0) | 2 (2) | 0.490 |
In glomeruli, n (%) | 1 (1) | 0 (0) | 1 (1) | 0.627 |
In arterioles, n (%) | 1 (1) | 0 (0) | 1 (1) | 0.627 |
Factor Ba positive, n (%) | 14/57 (25) | 5/20 (25) | 19/77 (25) | 0.969 |
In glomeruli, n (%) | 14/57 (25) | 5/20 (25) | 19/77 (25) | 0.969 |
In arterioles, n (%) | 0 (0) | 0 (0) | 0 (0) | NA |
