Table 3 Pathological data, mPDCD1 results and follow-up of 69 cases of Merkel cell carcinoma

From: PD-1 (PDCD1) promoter methylation in Merkel cell carcinoma: prognostic relevance and relationship with clinico-pathological parameters

Cases

TNMp

Pathological stage

Angioinvasion

Immune cells

Merkel cell polyomavirus

Tumor thickness

mPDCD1

Outcome (months)

1

T2 N1b M0

IIIB

No

0

0

0

High

no evidence of disease (12)

2

T0 N1b M0

IIIA

 

1

1

 

Low

no evidence of disease (24)

3

T2 Nx M0

 

No

1

1

1

High

dead of disease (36)

4

T2 N0 M0

IIA

No

0

1

1

High

no evidence of disease (72)

5

T2 N0 M0

IIA

No

0

0

0

High

no evidence of disease (84)

6

T2 N1b M0

IIIB

No

1

1

1

Low

no evidence of disease (96)

7

T2 N0 M0

IIA

No

0

1

0

Low

no evidence of disease (132)

8

T1 N1b M0

IIIB

Yes

1

1

0

Low

no evidence of disease (108)

9

T2 N1b M1c

IV

No

0

1

1

High

dead of disease (16)

10

T3 Nx M0

 

No

0

0

1

Low

no evidence of disease (24)

11

T1 Nx M0

 

No

1

1

0

Low

no evidence of disease (120)

12

T1 Nx M0

 

Yes

0

0

0

High

dead of disease (33)

13

T0 N1b M0

IIIA

 

0

0

 

Low

no evidence of disease (67)

14

T2 Nx M0

 

Yes

1

1

1

Low

no evidence of disease (80)

15

T2 Nx M0

 

Yes

0

0

1

High

dead of disease (8)

16

T0 N1b M0

IIIA

 

0

0

 

Low

dead of other causes (60)

17

T2 N1b M0

IIIB

Yes

1

1

0

Low

dead of disease (3)

18

T0 N1b M0

IIIA

 

0

1

 

High

dead of disease (30)

19

T2 N1b M0

IIIB

Yes

1

1

1

Low

dead of disease (24)

20

T2 N1b M1c

IV

Yes

1

1

0

Low

dead of disease (2)

21

T2 N1a M0

IIIA

Yes

0

0

1

High

dead of disease (31)

22

T2 N1b M0

IIIB

No

0

0

0

High

dead of disease (7)

23

T3 N2 M0

IIIB

No

1

0

0

Low

dead of disease (21)

24

T3 N1b M0

IIIB

No

0

0

1

High

dead of disease (5)

25

T2 N1b M0

IIIB

Yes

0

0

1

High

dead of disease (8)

26

T1 Nx M0

 

No

0

0

0

High

dead of disease (20)

27

T1 Nx M0

 

No

1

0

0

Low

no evidence of disease (83)

28

T1 Nx M0

 

Yes

0

1

0

High

dead of disease (51)

29

T1 Nx M0

 

No

0

1

0

Low

no evidence of disease (146)

30

T2 Nx M0

 

No

0

0

1

High

dead of disease (11)

31

T1 Nx M0

 

No

1

1

0

Low

dead of other causes (18)

32

T1 N1b M0

IIIB

No

0

0

0

High

dead of disease (30)

33

T1 Nx M0

 

No

1

1

0

Low

alive with disease (26)

34

T1 N3 M0

IIIB

No

1

1

0

Low

alive with disease (76)

35

T2 Nx M0

 

Yes

1

1

0

Low

no evidence of disease (33)

36

T2 Nx M0

 

Yes

0

1

0

High

dead of disease (46)

37

T1 N1b M0

IIIB

Yes

0

0

1

Low

dead of disease (32)

38

T1 Nx M0

 

Yes

1

0

1

Low

no evidence of disease (180)

39

T3 Nx M0

 

Yes

0

0

1

Low

dead of disease (25)

40

T1 Nx M0

 

No

0

0

0

High

no evidence of disease (8)

41

T2 Nx M0

 

Yes

0

0

1

Low

dead of disease (18)

42

T4 Nx M0

 

Yes

0

1

1

High

dead of disease (8)

43

T2 N1b M0

IIIB

Yes

0

0

1

High

dead of disease (25)

44

T3 N1b M0

IIIB

Yes

1

0

1

Low

dead of disease (12)

45

T1 N1a M0

IIIA

Yes

1

1

1

Low

alive with disease (33)

46

T4 N1a M0

IIIA

Yes

1

0

1

Low

alive with disease (48)

47

T2 Nx M0

 

Yes

1

1

1

Low

no evidence of disease (30)

48

T3 Nx M0

 

No

1

1

1

Low

no evidence of disease (178)

49

T2 N1b M0

IIIB

Yes

1

0

1

Low

dead of disease (7)

50

T1 Nx M0

 

Yes

0

0

1

High

no evidence of disease (31)

51

T1 Nx M0

 

No

1

1

0

Low

no evidence of disease (172)

52

T1 Nx M0

 

Yes

1

0

0

Low

dead of other causes (16)

53

T4 Nx M0

 

Yes

1

1

1

Low

dead of disease (23)

54

T1 N1b M0

IIIB

Yes

1

1

1

Low

alive with disease (54)

55

T4 Nx M0

 

Yes

0

0

0

High

dead of disease (20)

56

T2 Nx M0

 

Yes

1

0

1

High

dead of disease (69)

57

T2 Nx M0

 

Yes

1

0

1

Low

dead of disease (2)

58

T1 Nx M0

 

Yes

1

1

1

Low

no evidence of disease (37)

59

T2 Nx M0

 

No

0

1

1

High

alive with disease (10)

60

T2 Nx M0

 

Yes

1

0

1

Low

dead of other causes (14)

61

T2 Nx M0

 

Yes

0

0

1

High

dead of disease (72)

62

T3 Nx M0

 

Yes

1

0

1

Low

dead of disease (25)

63

T1 Nx M0

 

Yes

0

1

1

High

no evidence of disease (78)

64

T1 Nx M0

 

No

1

1

0

High

no evidence of disease (12)

65

T1 Nx M0

 

No

1

1

0

Low

alive with disease (29)

66

T2 Nx M0

 

Yes

0

0

0

High

no evidence of disease (36)

67

T1 Nx M0

 

No

0

1

0

Low

alive with disease (23)

68

T1 Nx M0

 

Yes

1

1

1

Low

no evidence of disease (13)

69

T2 Nx M0

 

Yes

1

1

1

Low

alive with disease (84)

  1. for cases presenting with lymphnode metastasis with unknown primary tumor (cases 2, 13, 16, and 18), growth pattern and angioinvasion have notbeen reported. For cases without pathological lymphnode evaluation (e.g., sentinel lymph node biopsy or lymphnode dissection) pN status and pathological stage have not been assessed
  2. mPDCD1 methylation status of PDCD1. Immune cells (0: absent; 1: present); Merkel cell polyomavirus (0: absent; 1: present); tumor thickness (0: <10 mm; 1: ≥10 mm)