Table 1 Clinicopathologic features of colon cancer stratified by SATB2 and CDX2 immunohistochemical expression
From: SATB2 and CDX2 are prognostic biomarkers in DNA mismatch repair protein deficient colon cancer
Clinical and pathologic features | Negative SATB2 expression N (%) | Positive SATB2 expression N (%) | p-value | Negative CDX2 expression N (%) | Positive CDX2 expression N (%) | p-value |
|---|---|---|---|---|---|---|
No. of patientsa | 67 (13) | 432 (87) | NA | 55 (11) | 451 (89) | NA |
Gender, male/female | 26 (39)/41 (61) | 212 (49)/220 (51) | 0.1 | 20 (36)/35 (64) | 218 (48)/233 (52) | 0.09 |
Mean age in years (range) | 69 (33–98) | 68 (23–95) | 0.5 | 69 (33–98) | 68 (23–95) | 0.5 |
Tumor locationa | ||||||
Cecum | 18 (27) | 89 (21) | 0.01 | 16 (29) | 93 (21) | 0.004 |
Right colon | 34 (51) | 164 (38) | 30 (55) | 169 (38) | ||
Left colon | 15 (22) | 179 (41) | 9 (16) | 186 (41) | ||
Mean tumor size (cm) (range) | 5.2 (0.2–13.4) | 4.9 (0.2–13.5) | 0.5 | 5.2 (0.2–13.4) | 4.9 (0.2–13.5) | 0.5 |
Stage | ||||||
I | 7 (10) | 63 (15) | 0.6 | 4 (7) | 66 (15) | 0.4 |
II | 23 (34) | 161 (37) | 25 (45) | 165 (37) | ||
III | 27 (40) | 140 (32) | 18 (33) | 148 (33) | ||
IV | 10 (15) | 68 (16) | 8 (15) | 72 (16) | ||
No. cases with histologic review performed | 44 | 313 | NA | 24 | 338 | NA |
High tumor grade | 18 (41) | 33 (11) | <0.001 | 12 (50) | 42 (12) | <0.001 |
High tumor budding | 18 (41) | 90 (29) | 0.1 | 7 (29) | 101 (30) | 0.9 |
Lymphatic invasion | 30 (68) | 161 (51) | 0.04 | 20 (83) | 174 (51) | 0.002 |
Venous invasion | 17 (39) | 70 (22) | 0.02 | 10 (42) | 78 (23) | 0.04 |
Perineural invasion | 16 (36) | 69 (22) | 0.04 | 10 (42) | 75 (22) | 0.03 |
Mucinous differentiation | 22 (50) | 79 (25) | 0.002 | 9 (38) | 96 (28) | 0.1 |
Signet ring cell differentiation | 7 (16) | 8 (3) | <0.001 | 2 (8) | 15 (4) | 0.4 |
Tumor infiltrating lymphocytes | 9 (20) | 57 (18) | 0.7 | 11 (46) | 56 (17) | <0.001 |
