Table 2 Status of the selected immunohistochemical and molecular markers
From: Spinal cord high-grade infiltrating gliomas in adults: clinico-pathological and molecular evaluation
Case ID | H3K27M | H3K27 me3 | IDH1/IDH2 | ATRX | TERT promoter | BRAF V600E | Other alteration(s) detected |
|---|---|---|---|---|---|---|---|
1 | Negative | Retained | Negative | Retained | Negative | Negative | |
2 | Positive | Lost | Negative | Retained | Negative | Negative | |
3 | Negative | Lost | Negative | Retained | Negative | Negative | TP53=p.Arg282Gly, P53=OE-Large |
4 | Negative | Retained | Negative | Retained | Positive | Negative | PIK3CA= p.Glu542Lys, TP53=p.Arg273His, EGFR=p.Val774Met, SETD2=p.Asn1392Thrfs*2 |
5 | Positive | Lost | Negative | Retained | Negative | Negative | |
6 | Negative | Negative | Retained | Positive | Negative | PIK3CA=p.Glu545Gln, | |
7 | Positive | Lost | Negative | Lost | Negative | Negative | NF1=p.Lys471Asnfs*2; p.Glu318Lysfs*11, PPM1D=p.Glu475Lysfs*8 |
8 | Negative | Retained | Negative | Retained | Negative | Negative | NF1=p.Asn1683_Thr1690del, PPM1D=p.Trp427X |
9 | Positive | Lost | Negative | Retained | Negative | Negative | BCOR=p.Arg1163X, TP53=p.Gly245Ser |
10 | Positive | Lost | Negative | Retained | Negative | Negative | TP53=p.Val173Leu |
11 | Negative | Retained | Negative | Retained | Negative | Negative | TP53=p.Arg306X |
12 | Negative | Retained | Negative | Retained | Positive | Negative | |
13 | Positive | Lost | Negative | Retained | Negative | Negative | NF1=p.Arg385Valfs*2, PPM1D=p.Arg385Valfs*2 |
