Table 1 Correlation between COL11A1 expression with different clinicopathological parameters in the pure DCIS cohort
From: Collagen (XI) alpha-1 chain is an independent prognostic factor in breast ductal carcinoma in situ
Clinicopathological Parameters | COL11A1 expression in tumor epithelial cells | χ2 (p-value) | COL11A1 expression in stromal fibroblasts | χ2 (p-value) | ||
|---|---|---|---|---|---|---|
Low (N = 338) N. (%) | High (N = 110) N. (%) | Low (N = 391) N. (%) | High (N = 57) N. (%) | |||
Age (years) | 1.2 (0.280) | |||||
≤ 50 | 81 (24) | 27 (25) | 0.1 | 91 (23) | 17 (30) | |
> 50 | 257 (76) | 83 (75) | (0.902) | 300 (77) | 40 (70) | |
Presentation | 0.6 (0.438) | |||||
Screening | 166 (49) | 52 (47) | 0.1 | 193 (49) | 25 (44) | |
Symptomatic | 172 (51) | 58 (53) | (0.737) | 198 (51) | 32 (56) | |
DCIS size (mm) | 2.6 (0.106) | |||||
≤ 20 | 147 (44) | 51 (47) | 0.4 | 163 (43) | 30 (54) | |
> 20 | 191 (56) | 57 (53) | (0.497) | 223 (57) | 25 (46) | |
Nuclear grade | 1.6 (0.457) | |||||
Low | 40 (12) | 13 (12) | 0.2 | 49 (13) | 4 (7) | |
Moderate | 88 (26) | 31 (28) | (0.903) | 102 (26) | 17 (30) | |
High | 210 (62) | 66 (60) | 240 (61) | 36 (63) | ||
Comedo necrosis | 0.1 (0.716) | |||||
Yes | 221 (65) | 76 (69) | 0.5 | 258 (66) | 39 (68) | |
No | 117 (35) | 34 (31) | (0.475) | 133 (34) | 18 (32) | |
Estrogen receptor | 9.8 (0.002) | |||||
Negative | 77 (25) | 34 (33) | 2.6 | 87 (24) | 24 (44) | |
Positive | 233 (75) | 69 (67) | (0.105) | 272 (76) | 30 (56) | |
Progesterone receptor | 4.1 (0.042) | |||||
Negative | 119 (38) | 53 (52) | 6.3 | 144 (40) | 28 (55) | |
Positive | 192 (62) | 48 (48) | (0.012) | 217 (60) | 23 (45) | |
HER2 status | 1.5 (0.211) | |||||
Negative | 231 (76) | 75 (74) | 0.2 | 289 (77) | 39 (70) | |
Positive | 74 (24) | 27 (26) | (0.655) | 85 (23) | 17 (30) | |
Proliferation index (Ki-67) | 3.8 (0.049) | |||||
High | 62 (23) | 25 (24) | 0.1 | 70 (22) | 17 (34) | |
Low | 210 (77) | 78 (76) | (0.762) | 255 (78) | 33 (66) | |
Molecular classes | 8.2 (0.041) | |||||
Luminal A | 139 (54) | 47 (48) | 1.5 (0.685) | 167 (54) | 19 (38) | |
Luminal B | 47 (18) | 18 (18) | 57 (18) | 8 (16) | ||
HER2 Enriched | 40 (15) | 17 (17) | 43 (14) | 14 (28) | ||
Triple negative | 34 (13) | 17 (17) | 42 (14) | 9 (18) | ||
Tumor infiltrating lymphocytes | 5.9 (0.016) | |||||
Dense | 122 (47) | 49 (57) | 2.5 (0.113) | 140 (47) | 31 (66) | |
Sparse | 137 (53) | 37 (43) | 158 (53) | 16 (34) | ||
HIF1A expression | ||||||
High | 58 (24) | 26 (29) | 1.1 | 63 (22) | 21 (48) | 13.8 (<0.0001) |
Low | 188 (76) | 63 (71) | (0.293) | 228 (78) | 23 (52) | |
